Endocrine Abstracts

Type 1 diabetes mellitus (T1DM) is one of the most frequent autoimmune disorders in childhood, adolescence and youth, developing due to autoimmune destruction of pancreatic β-cells, which leads to an absolute insulin deficiency. Gut microbiota (GM) is associated with the functions of the body’s immune system, and immune-mediated diseases, including T1DM. However, the exact mechanisms by which GM is involved in the T1DM are still unknown. Accumulating data suggest tha...

Introduction: Incidence of type 1 diabetes mellitus (T1DM) is rising steadily around the globe, including Armenia. It is one of the most common autoimmune and metabolic disorders in pediatric population, resulting from autoimmune destruction of pancreatic β-cells leading to insulin deficiency. Gut microbiota (GM) is reportedly involved in the pathogenesis of T1DM likely by influencing the immune response with the help of arginine-metabolizing enzymes. Arginase i...